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Glycoengineering (Protein Glycan Analysis & Design)

Scans protein sequences for N-/O-glycosylation sites and guides glycan engineering for therapeutic antibodies and vaccine antigens.

Data & AnalyticsAdvanced★ 33,030⑂ 3,248AI score 7/10Last updated: Aug 9, 2026

What it does

Turns Claude into a glycosylation analysis and design assistant:

  • N-glycosylation sequon scanning: finds the N-X-[S/T] motif (X ≠ Pro) and reports 1-based positions, ±3-residue context, NXS vs NXT classification, and a summary log.
  • Site add/remove mutagenesis: knocks out glycosites with a conservative Asn → Gln swap, or engineers a new sequon by installing Asn, removing a +1 proline, and forcing S/T at +2.
  • Heuristic O-glycosylation hotspot prediction: sliding-window Ser/Thr density scoring with an S/T-Pro inhibition rule as a fast baseline before NetOGlyc.
  • Curated external tooling: NetNGlyc / NetOGlyc 4.0, GlycoShield-MD, GlycoWorkbench, the GlyConnect REST API, UniCarbKB, GlyTouCan.
  • Strategy tables: boosting ADCC via Asn297 afucosylation, cutting immunogenicity (α-Gal, NGNA), extending half-life via sialylation, building vaccine glycan shields, plus classic mutations (N297A/Q/D, T299A, S298A/E333A/K334A) and IUPAC glycan notation.

Who it's for

  • Antibody engineers tuning Fc glycans for effector function or aglycosyl formats
  • Analytical scientists comparing glycan profiles for biosimilar characterization
  • Vaccine designers building glycan shields to focus responses on conserved epitopes
  • Protein engineers adding N-glycans to improve stability or pharmacokinetics

Examples

  1. "Scan this IgG1 Fc sequence for all N-glycosylation sequons and tabulate positions with context" → report that surfaces the Asn297 site.
  2. "Give me an aglycosyl variant of this heavy chain and compare the mutation options" → mutated N297Q sequence plus a comparison of N297A/D and T299A.
  3. "Estimate where O-glycans cluster in this mucin-like domain and tell me how to confirm it" → S/T-density hotspot list plus NetOGlyc 4.0 submission guidance.

· · · Install guide · · ·

Install in the Claude app (no terminal)
  1. Download the ZIP with the button below.
  2. In Claude, open Settings → Capabilities and turn on 'Code execution and file creation'. (one time)
  3. Go to Customize → Skills → + → 'Upload a skill' and upload the ZIP.
↓ Download ZIP
Install in Claude Code

Let Claude do it — paste this into Claude Code

Install the skill I found on Claude Skill Mart.
Copy the skills/glycoengineering folder from the GitHub repo K-Dense-AI/scientific-agent-skills into my ~/.claude/skills/glycoengineering/.
When it's done, tell me in one line what this skill can do.

Install with a command instead

git clone https://github.com/K-Dense-AI/scientific-agent-skills.git /tmp/sci-skills && mkdir -p ~/.claude/skills && cp -r /tmp/sci-skills/skills/glycoengineering ~/.claude/skills/

⚠ This is a third-party skill. Check the source repository before installing.

  1. Open a terminal (macOS Terminal, or WSL / Git Bash on Windows).
  2. Create the skills directory: mkdir -p ~/.claude/skills
  3. Clone the repository into a temp folder: git clone https://github.com/K-Dense-AI/scientific-agent-skills.git /tmp/sci-skills
  4. Copy just this skill: cp -r /tmp/sci-skills/skills/glycoengineering ~/.claude/skills/
  5. Verify with ls ~/.claude/skills/glycoengineering — you should see SKILL.md.
  6. To run the included code, install Python 3 and requests (needed for GlyConnect queries): pip install requests
  7. Restart Claude Code and try: "Analyze the N-glycosylation sites in this protein sequence."
  8. (Optional) For glycan shielding MD analysis, install the extra tool: uv pip install glycoshield.
View source on GitHub ↗License: MIT